Opportunity Information: Apply for HT942526BMFRPRDA
The FY26 Bone Marrow Failure Research Program (BMFRP) Resource Development Award (RDA) is a grant opportunity from the Defense Health Agency intended to build a major shared research asset for the bone marrow failure (BMF) field. The core purpose of the award is to support development of a multiomic atlas created from well-annotated human BMF samples, where the omic data are generated directly from bone marrow specimens. In practical terms, this means applicants are expected to assemble, analyze, and organize multiple layers of molecular information from marrow-derived samples (for example, complementary genomic, transcriptomic, epigenomic, proteomic, or related modalities) and connect those data to high-quality sample and clinical annotations so the resulting dataset can meaningfully support biological discovery and clinical translation.
A defining expectation of this funding mechanism is that the final product is not just a one-off dataset for a single research group, but a durable, open-access resource that can be broadly used by both the research community and clinicians. The program frames the atlas as an enabling platform designed to accelerate key discoveries and improve understanding of bone marrow failure diseases, implying that the resource should be structured for long-term utility, reuse, and integration into future studies. Because the award is focused on resource development, the emphasis is on creating a well-curated, high-value reference dataset that others can mine to generate new hypotheses, compare across cohorts, and potentially identify biomarkers, mechanisms, or clinically relevant subtypes.
Another distinctive requirement is the need for a robust Data Resource Sharing Plan. Applications must clearly describe how the fully developed resource will be made available to the broader scientific and clinical community, and when. This plan is central to the award: it should lay out the mechanism(s) of distribution (such as repositories or platforms), access conditions consistent with open access and human-subject protections, and a concrete timeline for release. The opportunity makes clear that sharing is not an afterthought; it is part of the program design and is expected to be addressed in a detailed, credible way that matches the scale and ambition of the proposed atlas.
Administratively, the opportunity is a discretionary grant in the science and technology / research and development category (CFDA 12.420). The funding opportunity number is HT942526BMFRPRDA, and it is offered by the Defense Health Agency Contracting Activity (DHACA). Eligibility is listed as unrestricted, and the program anticipates making a single award. The original closing date is November 4, 2026, and the opportunity was created on June 17, 2026. The award ceiling is not specified in the provided notice, so applicants would need to consult the full solicitation materials or related guidance for budget limits and any cost constraints.Apply for HT942526BMFRPRDA
- The Defense Health Agency Contracting Activity - DHACA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoW Bone Marrow Failure, Resource Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2026-06-17.
- Applicants must submit their applications by 2026-11-04. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted.
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FY26 Bone Marrow Failure Research Program (BMFRP) Resource Development Award (RDA) FAQs
What is the FY26 BMFRP Resource Development Award (RDA)?
The FY26 Bone Marrow Failure Research Program (BMFRP) Resource Development Award (RDA) is a discretionary government grant opportunity from the Defense Health Agency. It is designed to fund development of a major shared research asset for the bone marrow failure (BMF) field, rather than supporting a single-lab, single-purpose research dataset.
What is the main goal of this award?
The core purpose is to support development of a multiomic atlas built from well-annotated human bone marrow failure samples, where the omic data are generated directly from bone marrow specimens. The atlas is intended to be an enabling platform that accelerates discovery and improves understanding of bone marrow failure diseases.
What kind of resource is expected as the final product?
The expected final product is a durable, open-access resource that can be broadly used by both the research community and clinicians. The program emphasizes long-term utility, reuse, and the ability for the resource to be integrated into future studies, not just a one-off dataset for a single group.
What does "multiomic atlas" mean in the context of this opportunity?
In this opportunity, a multiomic atlas refers to a structured collection of multiple layers of molecular data generated from bone marrow-derived specimens. Examples of omic layers referenced include complementary genomic, transcriptomic, epigenomic, proteomic, or related modalities, organized in a way that supports meaningful analysis and interpretation.
Do the omic data have to be generated from bone marrow specimens specifically?
Yes. The opportunity explicitly states that the omic data should be generated directly from bone marrow specimens, and the atlas is described as being created from marrow-derived samples.
What does "well-annotated human BMF samples" imply?
Based on the description, it implies that the bone marrow failure samples should have high-quality sample and clinical annotations and that these annotations should be linked to the generated omic data so the resulting dataset can support biological discovery and clinical translation.
Is this award meant to fund a single research group’s internal dataset?
No. A defining expectation is that the resource will not be a one-off dataset intended only for a single research group. The final product is expected to be a shared, open-access resource intended for broad use.
Who is expected to use the resulting atlas?
The opportunity states that the resource should be broadly usable by both the research community and clinicians, indicating it should be organized and shared in a way that supports both scientific investigation and clinically relevant applications.
What is the emphasis of the award: hypothesis-driven research or resource development?
The emphasis is on resource development. The opportunity highlights creating a well-curated, high-value reference dataset that others can mine to generate new hypotheses, compare across cohorts, and potentially identify biomarkers, mechanisms, or clinically relevant subtypes.
What is a Data Resource Sharing Plan, and is it required?
A robust Data Resource Sharing Plan is a central requirement of this award. Applications must clearly describe how the fully developed resource will be made available to the broader scientific and clinical community, and when it will be released.
How important is the Data Resource Sharing Plan for this award?
It is described as central to the award and not an afterthought. The plan is expected to be detailed and credible, matching the scale and ambition of the proposed atlas.
What should the Data Resource Sharing Plan include, based on the notice?
Based on the provided information, the plan should include: (1) the mechanism(s) of distribution (such as repositories or platforms), (2) access conditions consistent with open access and human-subject protections, and (3) a concrete timeline for resource release.
Does the opportunity specify how the resource must be shared (for example, a particular repository)?
No specific repository or platform is named in the information provided. The notice indicates that applicants should describe the mechanism(s) of distribution, such as repositories or platforms, and present a clear approach and timeline.
What does "open access" mean here?
Within the context of the opportunity description, open access means the resource should be made available to the broader scientific and clinical community. The notice also indicates access conditions should be consistent with human-subject protections, suggesting sharing should be designed to enable broad use while respecting required protections.
What federal category and CFDA number is associated with this opportunity?
The opportunity is listed in the science and technology / research and development category, with CFDA 12.420.
What is the funding opportunity number?
The funding opportunity number is HT942526BMFRPRDA.
Which agency is offering this opportunity?
The opportunity is offered by the Defense Health Agency Contracting Activity (DHACA) and is described as a Defense Health Agency grant opportunity.
Is eligibility restricted?
Eligibility is listed as unrestricted.
How many awards does the program anticipate making?
The program anticipates making a single award.
What is the application closing date?
The original closing date is November 4, 2026.
When was the opportunity created?
The opportunity was created on June 17, 2026.
Is there an award ceiling or maximum budget listed?
No. The award ceiling is not specified in the provided notice. Applicants are expected to consult the full solicitation materials or related guidance for budget limits and any cost constraints.
What types of discoveries or downstream uses does the program expect the atlas to enable?
The notice describes the atlas as an enabling platform designed to accelerate key discoveries and improve understanding of bone marrow failure diseases. It also notes that the resource should support biological discovery and clinical translation, including enabling others to mine the dataset for new hypotheses, compare across cohorts, and potentially identify biomarkers, mechanisms, or clinically relevant subtypes.
Does the notice require the atlas to be designed for long-term use?
Yes. The program frames the atlas as a durable resource structured for long-term utility, reuse, and integration into future studies.
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