Opportunity Information: Apply for RFA HD 23 007
The CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect (P50) funding opportunity (RFA-HD-23-007) is a National Institutes of Health discretionary grant announcement designed to build one or more specialized, multidisciplinary research centers that function as a national hub for child maltreatment research. Using the P50 specialized center mechanism, the program is meant to support integrated, high-impact research programs that go beyond single-project studies by combining multiple coordinated research efforts, shared scientific resources, and field-facing engagement. Clinical trials are allowed but not required, making the opportunity flexible for applicants proposing either intervention testing or other rigorous clinical and translational research designs.
At its core, the FOA is focused on generating innovative, high-quality evidence that can improve how child abuse and neglect are identified, understood, and treated, with the explicit goal of reducing morbidity and mortality and clarifying related health consequences. The research scope spans several major priority areas. First, the Centers are expected to conduct trials that test the efficacy and real-world effectiveness of clinical interventions, supporting work that can move from controlled settings into everyday practice. Second, the FOA calls for longitudinal, prospective studies that examine long-term outcomes of specific and understudied forms of maltreatment, with examples including abusive head trauma, medical child abuse and neglect, and chronic sexual abuse. This emphasis signals an interest in stronger causal inference and clearer developmental trajectories over time, especially for maltreatment types that are difficult to study but carry significant risk.
A third major area is neurobiology, with the FOA encouraging studies that investigate the neurobiological effects of abuse and neglect and how those biological changes relate to later health outcomes. This can include work that connects early adverse experiences to brain development, stress physiology, mental health, chronic disease risk, or other measurable pathways that help explain why maltreatment can have enduring effects. Fourth, the FOA prioritizes research on tools for early identification and clinical management, including the development and testing of screening instruments and clinical assessment measures. The intent is to improve timely detection of specific maltreatment presentations, support earlier treatment, and better identify comorbidities that may complicate care or increase risk.
In addition to the research components, applicants must include a dissemination and outreach core, which is positioned as a central requirement rather than an optional add-on. This core is expected to translate the Center's research into accessible, usable knowledge and to create exposure and learning opportunities for students and faculty at different career stages. A key expectation is active engagement with both scientific audiences and frontline professional communities through participatory activities. The FOA lists examples such as technical assistance, evidence-based practice support, grand rounds, conferences and seminars, and webinars, with the format tailored to the Center's strengths and the needs of the communities it serves. In practical terms, this means the Center should not only generate evidence, but also help it travel into clinical, educational, and service settings where it can change practice.
Eligibility is broad and includes many types of U.S. governmental entities and organizations, such as state, county, and local governments; special districts; independent school districts; public housing authorities/Indian housing authorities; and federally recognized tribal governments, as well as tribal organizations that are not federally recognized. The FOA also allows a wide range of academic and nonprofit applicants, including public and state-controlled institutions of higher education, private institutions of higher education, and nonprofits with or without 501(c)(3) status. For-profit organizations (other than small businesses) and small businesses are also listed as eligible, along with additional categories specifically highlighted in the announcement, such as Historically Black Colleges and Universities, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, faith-based and community-based organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations and regional organizations. The activity category aligns with Health, Income Security and Social Services under CFDA 93.865.
Key administrative details from the source information include an original closing date of July 27, 2022, and a creation date of March 7, 2022. While the provided excerpt does not specify the award ceiling or expected number of awards, the structure and goals clearly indicate the NIH intent to support substantial, center-level programs that integrate multiple research projects with shared cores and an outward-facing dissemination function, ultimately positioning the funded Center(s) as a national resource for advancing the science and practice of preventing, detecting, and responding to child abuse and neglect.Apply for RFA HD 23 007
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect (P50) (Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2022-03-07.
- Applicants must submit their applications by 2022-07-27. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect (P50) - RFA-HD-23-007
What is the CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect (P50) opportunity?
This funding opportunity (RFA-HD-23-007) is a National Institutes of Health (NIH) discretionary grant announcement to build one or more specialized, multidisciplinary research centers that function as a national hub for child maltreatment research. It uses the P50 specialized center mechanism to support integrated, coordinated research programs rather than single, stand-alone projects.
What is the main purpose of creating a CAPSTONE Center?
The core purpose is to generate innovative, high-quality evidence that improves how child abuse and neglect are identified, understood, and treated, with an explicit goal of reducing morbidity and mortality and clarifying related health consequences. The center structure is intended to create a national resource that advances both science and real-world practice.
How is a P50 center different from a single research project grant?
Based on the description provided, the P50 mechanism is meant to support integrated, high-impact research that goes beyond single-project studies by combining multiple coordinated research efforts, shared scientific resources (shared cores), and field-facing engagement through dissemination and outreach.
Are clinical trials required under this funding opportunity?
No. Clinical trials are allowed but not required. This means applicants may propose intervention testing (including efficacy and effectiveness trials) or other rigorous clinical and translational research designs.
What kinds of research topics are prioritized?
The opportunity highlights several major priority areas: (1) trials that test efficacy and real-world effectiveness of clinical interventions, (2) longitudinal prospective studies on long-term outcomes of specific and understudied forms of maltreatment, (3) neurobiology research on the biological effects of abuse and neglect and links to later outcomes, and (4) research on early identification and clinical management tools, including screening instruments and clinical assessment measures.
Does the FOA emphasize real-world implementation or only controlled research settings?
It explicitly calls for research that can move from controlled settings into everyday practice. In particular, it mentions testing both efficacy and real-world effectiveness of clinical interventions, indicating interest in practical applicability.
What does the FOA say about longitudinal research?
It calls for longitudinal, prospective studies that examine long-term outcomes of specific and understudied forms of maltreatment. The emphasis suggests interest in stronger causal inference and clearer developmental trajectories over time.
Which forms of maltreatment are specifically mentioned as examples for longitudinal study?
The examples listed include abusive head trauma, medical child abuse and neglect, and chronic sexual abuse.
What neurobiology-related research is encouraged?
The FOA encourages studies investigating the neurobiological effects of abuse and neglect and how those biological changes relate to later health outcomes. Examples include connections to brain development, stress physiology, mental health, chronic disease risk, or other measurable pathways that explain enduring effects of maltreatment.
What does the FOA prioritize regarding early identification and clinical management?
It prioritizes research on tools for early identification and clinical management, including development and testing of screening instruments and clinical assessment measures. The intent is to improve timely detection of specific maltreatment presentations, support earlier treatment, and better identify comorbidities that may complicate care or increase risk.
Is a dissemination and outreach component required?
Yes. Applicants must include a dissemination and outreach core, described as a central requirement rather than an optional add-on. This core is expected to translate research into accessible, usable knowledge and create exposure and learning opportunities for students and faculty at different career stages.
What types of dissemination and outreach activities are mentioned?
Examples listed include technical assistance, evidence-based practice support, grand rounds, conferences and seminars, and webinars. The FOA notes that the format should be tailored to the Center's strengths and the needs of the communities it serves.
Who is the dissemination and outreach core expected to engage?
The FOA expects active engagement with both scientific audiences and frontline professional communities through participatory activities.
Does the opportunity indicate that funded Centers should serve as a national resource?
Yes. The description states the Centers are intended to function as a national hub for child maltreatment research and positions the funded Center(s) as a national resource for advancing science and practice related to preventing, detecting, and responding to child abuse and neglect.
What types of organizations are eligible to apply?
Eligibility is described as broad. It includes many U.S. governmental entities and organizations (state, county, and local governments; special districts; independent school districts; public housing authorities/Indian housing authorities; federally recognized tribal governments; and tribal organizations not federally recognized), as well as academic institutions, nonprofits, for-profit organizations (other than small businesses), and small businesses. The announcement also highlights several institution and community categories and allows non-U.S. (foreign) organizations and regional organizations.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized tribal governments are included, and tribal organizations that are not federally recognized are also listed as eligible.
Are nonprofits required to have 501(c)(3) status to apply?
No. The eligibility list includes nonprofits with or without 501(c)(3) status.
Are for-profit entities eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Are institutions of higher education eligible?
Yes. The eligibility list includes public and state-controlled institutions of higher education as well as private institutions of higher education.
Are specific institution types (like HBCUs or HSIs) mentioned?
Yes. The announcement specifically highlights Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions (HSIs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs, among others.
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are included in the eligibility list.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed as eligible.
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility list includes non-U.S. (foreign) organizations and regional organizations.
What is the activity category or CFDA number associated with this opportunity?
The activity category aligns with Health, Income Security and Social Services under CFDA 93.865.
What are the key dates provided for this funding opportunity?
The source information lists a creation date of March 7, 2022, and an original closing date of July 27, 2022.
Does the provided information state the award ceiling or the expected number of awards?
No. The excerpt provided does not specify the award ceiling or the expected number of awards.
What does the structure of the program suggest about the scale of proposed work?
Even though the excerpt does not provide a funding ceiling, it describes an NIH intent to support substantial, center-level programs that integrate multiple research projects, shared cores, and an outward-facing dissemination function.
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