Opportunity Information: Apply for TI 25 005
The Hepatitis C Elimination Initiative Pilot (Funding Opportunity Number TI 25 005) is a discretionary grant program from the Substance Abuse and Mental Health Services Administration (SAMHSA) designed as a proof-of-concept effort to accelerate hepatitis C (HCV) prevention, testing, treatment, and cure among people who are often missed by traditional health systems. The central idea is to build on the capacity that health care institutions already have and use it more effectively to reach individuals with substance use disorder (SUD) and/or severe mental illness (SMI), with a particular emphasis on communities heavily impacted by homelessness. In addition to expanding access to curative treatment, the program is also meant to generate practical insights about what actually works in real-world settings for finding patients, supporting them through completion of treatment, and reducing the risk of reinfection after cure.
The opportunity prioritizes integrated, on-the-ground approaches that connect behavioral health and medical care, since SUD and SMI can create barriers to HCV diagnosis and follow-through on treatment. Projects funded under this pilot are expected to focus not only on clinical delivery (screening, confirmatory testing, and providing curative therapy) but also on the operational strategies that improve engagement and retention. That includes methods to identify and reach eligible patients, streamline care so people can move from testing to treatment quickly, and design supports that make it more likely someone will complete treatment despite instability related to housing, mental health symptoms, or ongoing substance use. A core learning goal of the pilot is to understand how programs can reduce reinfection, which commonly requires pairing treatment with prevention services and ongoing engagement.
Eligible applicants are broad and include States and Territories (including the District of Columbia), political subdivisions of States, Indian tribes and tribal organizations (as defined in 25 U.S.C. 5304), and health facilities or programs operated by or in accordance with an Indian Health Service contract or award. The program also allows other public or private non-profit entities to apply, including faith-based organizations. This wide eligibility is meant to encourage partnerships across public health agencies, behavioral health providers, homeless service systems, and community-based organizations that already serve high-need populations.
Key administrative details include an award ceiling of $7,500,000, with an anticipated 40 awards. The program is categorized under the Health funding activity category, uses the grant funding instrument, and is listed under CFDA number 93.243. The opportunity was created on 2025-07-15, and the original application closing date is 2025-08-01.Apply for TI 25 005
- The Substance Abuse and Mental Health Services Adminis in the health sector is offering a public funding opportunity titled "Hepatitis C Elimination Initiative Pilot" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.243.
- This funding opportunity was created on 2025-07-15.
- Applicants must submit their applications by 2025-08-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $7,500,000.00 in funding.
- The number of recipients for this funding is limited to 40 candidate(s).
- Eligible applicants include: Others.
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Frequently Asked Questions (FAQs)
What is the Hepatitis C Elimination Initiative Pilot (Funding Opportunity Number TI 25 005)?
The Hepatitis C Elimination Initiative Pilot (Funding Opportunity Number TI 25 005) is a discretionary grant program from the Substance Abuse and Mental Health Services Administration (SAMHSA). It is designed as a proof-of-concept effort to accelerate hepatitis C (HCV) prevention, testing, treatment, and cure for people who are often missed by traditional health systems.
What is the main purpose of this funding opportunity?
The main purpose is to strengthen and better use existing health care capacity to reach people with substance use disorder (SUD) and/or severe mental illness (SMI), with a particular emphasis on communities heavily impacted by homelessness. The initiative supports projects that increase access to curative HCV treatment and generate practical, real-world lessons about how to find patients, support treatment completion, and reduce reinfection after cure.
Why does this pilot emphasize people with SUD and/or SMI?
The opportunity emphasizes people with SUD and/or SMI because these conditions can create barriers to HCV diagnosis and follow-through on treatment. The program prioritizes integrated approaches that connect behavioral health and medical care to improve engagement, retention, and successful completion of curative therapy.
Which populations are especially prioritized by this pilot?
The pilot places particular emphasis on communities heavily impacted by homelessness, alongside individuals living with SUD and/or SMI who may be missed by traditional health systems.
What types of approaches does SAMHSA prioritize under this pilot?
SAMHSA prioritizes integrated, on-the-ground approaches that connect behavioral health and medical care. Funded projects are expected to address both clinical delivery and the operational strategies that improve engagement and retention from testing through treatment completion.
What clinical activities are projects expected to focus on?
Projects are expected to focus on clinical delivery activities including screening, confirmatory testing, and providing curative therapy for hepatitis C.
Beyond clinical care, what operational strategies are expected?
In addition to screening and treatment, projects are expected to emphasize operational strategies that improve engagement and retention, such as methods to identify and reach eligible patients, streamline care to move people quickly from testing to treatment, and provide supports that increase the likelihood of completing treatment despite instability related to housing, mental health symptoms, or ongoing substance use.
Is reducing hepatitis C reinfection part of the pilot's goals?
Yes. A core learning goal of the pilot is to understand how programs can reduce reinfection after cure. This often requires pairing treatment with prevention services and ongoing engagement.
What is the program trying to learn or prove?
This is a proof-of-concept pilot intended to generate practical insights about what works in real-world settings for finding patients, supporting them through completion of treatment, and reducing reinfection after cure, especially among people who are often missed by traditional health systems.
Who is eligible to apply?
Eligible applicants include States and Territories (including the District of Columbia), political subdivisions of States, Indian tribes and tribal organizations (as defined in 25 U.S.C. 5304), and health facilities or programs operated by or in accordance with an Indian Health Service contract or award. Other public or private non-profit entities may also apply, including faith-based organizations.
Are faith-based organizations eligible?
Yes. The opportunity allows other public or private non-profit entities to apply, including faith-based organizations.
Do Indian tribes and tribal organizations qualify, and how are they defined?
Yes. Indian tribes and tribal organizations are eligible, as defined in 25 U.S.C. 5304.
Are Indian Health Service (IHS) facilities or programs eligible?
Yes. Health facilities or programs operated by, or in accordance with, an Indian Health Service contract or award are eligible.
Does this opportunity encourage partnerships?
Yes. The wide eligibility is intended to encourage partnerships across public health agencies, behavioral health providers, homeless service systems, and community-based organizations that already serve high-need populations.
What is the maximum award amount (award ceiling)?
The award ceiling is $7,500,000.
How many awards does SAMHSA anticipate making?
SAMHSA anticipates making 40 awards.
What is the funding activity category for this opportunity?
The funding activity category is Health.
What type of funding instrument is used?
The opportunity uses the grant funding instrument.
What is the CFDA number for this opportunity?
The CFDA number listed for this opportunity is 93.243.
When was this opportunity created?
The opportunity was created on 2025-07-15.
What is the original application closing date?
The original application closing date is 2025-08-01.
Is this program focused only on providing treatment?
No. While expanding access to curative treatment is a major component, the pilot also emphasizes prevention, testing, operational improvements to move people from testing to treatment quickly, and strategies to support treatment completion and reduce reinfection.
Does the opportunity specify the need to connect behavioral health and medical care?
Yes. The opportunity explicitly prioritizes integrated approaches that connect behavioral health and medical care, recognizing that SUD and SMI can create barriers to HCV diagnosis and treatment follow-through.
What kinds of barriers is the program designed to address?
The program is designed to address barriers related to housing instability, mental health symptoms, and ongoing substance use that can interfere with testing, starting treatment, and completing curative therapy.
What does "people who are often missed by traditional health systems" mean in this context?
In this context, it refers to individuals who may not reliably access or remain connected to conventional health care settings, including people with SUD and/or SMI and communities heavily impacted by homelessness.
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