Hepatitis C Elimination Initiative Pilot | TI 25 005

Opportunity Information: Apply for TI 25 005

The Hepatitis C Elimination Initiative Pilot (Funding Opportunity Number TI 25 005) is a discretionary grant program from the Substance Abuse and Mental Health Services Administration (SAMHSA) designed as a proof-of-concept effort to accelerate hepatitis C (HCV) prevention, testing, treatment, and cure among people who are often missed by traditional health systems. The central idea is to build on the capacity that health care institutions already have and use it more effectively to reach individuals with substance use disorder (SUD) and/or severe mental illness (SMI), with a particular emphasis on communities heavily impacted by homelessness. In addition to expanding access to curative treatment, the program is also meant to generate practical insights about what actually works in real-world settings for finding patients, supporting them through completion of treatment, and reducing the risk of reinfection after cure.

The opportunity prioritizes integrated, on-the-ground approaches that connect behavioral health and medical care, since SUD and SMI can create barriers to HCV diagnosis and follow-through on treatment. Projects funded under this pilot are expected to focus not only on clinical delivery (screening, confirmatory testing, and providing curative therapy) but also on the operational strategies that improve engagement and retention. That includes methods to identify and reach eligible patients, streamline care so people can move from testing to treatment quickly, and design supports that make it more likely someone will complete treatment despite instability related to housing, mental health symptoms, or ongoing substance use. A core learning goal of the pilot is to understand how programs can reduce reinfection, which commonly requires pairing treatment with prevention services and ongoing engagement.

Eligible applicants are broad and include States and Territories (including the District of Columbia), political subdivisions of States, Indian tribes and tribal organizations (as defined in 25 U.S.C. 5304), and health facilities or programs operated by or in accordance with an Indian Health Service contract or award. The program also allows other public or private non-profit entities to apply, including faith-based organizations. This wide eligibility is meant to encourage partnerships across public health agencies, behavioral health providers, homeless service systems, and community-based organizations that already serve high-need populations.

Key administrative details include an award ceiling of $7,500,000, with an anticipated 40 awards. The program is categorized under the Health funding activity category, uses the grant funding instrument, and is listed under CFDA number 93.243. The opportunity was created on 2025-07-15, and the original application closing date is 2025-08-01.

• The Substance Abuse and Mental Health Services Adminis in the health sector is offering a public funding opportunity titled "Hepatitis C Elimination Initiative Pilot" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.243.
• This funding opportunity was created on 2025-07-15.
• Applicants must submit their applications by 2025-08-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $7,500,000.00 in funding.
• The number of recipients for this funding is limited to 40 candidate(s).
• Eligible applicants include: Others.

Apply for TI 25 005

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